Adiponectin levels in women diagnosed with PCOS
Although adiponectin levels have been observed to be decreased in women with polycystic ovary syndrome (PCOS), these studies have failed to show any statistical significance. Karkanaki et al. (Fertil Steril 2009 Aug 21) recently published a study of adiponectin levels in PCOS patients, classified to four groups, depending on their clinical manifestations, compared to controls (group 5). Groups 1 and 2 were characterized as classic PCOS according to the criteria of National Institutes of Health of 1990, whereas groups 3 and 4 were classified as suggested in Rotterdam Consensus Statement, in 2003. Adiponectin levels were significantly lower in group 1 and 2, compared to groups 3 and 4, which showed much higher adiponectin levels reaching those of the controls. The authors conclude that adiponectin levels could reflect the distinct PCOS phenotypes and that previous conflicting scientific data, regarding the impact of PCOS on adiponectin levels, independently of obesity, could be attributed to the heterogeneity of studied populations.
Karkanaki et al. 2009 Adiponectin levels reflect the different phenotypes of polycystic ovary syndrome: study in normal weight, normoinsulinemic patients. Fertil Steril 2009 Aug 21 (Epub ahead of print)