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Insulin resistance

An effect of kidney donation.

Observed associations between renal dysfunction and increased cardiovascular morbidity have raised a growing concern about the risk of kidney donations. Insulin resistance plays a central role in enhancing cardiovascular morbidity in renal patients. However, it is controversial if the cause of insulin resistance is due to decreased glomerular filtration rate or enhanced inflammation.


Shehab-Eldin et al. (Am J Nephrol 30:371–376, 2009) studied the correlation of decreased glomerular filtration rate and increased levels of proinflammatory mediators with insulin resistance in nephrectomized patients. Several factors associated with insulin resistance were measured, among those insulin, proinsulin and adiponectin (measured with Mercodia assays) together with pro-inflammatory markers and HOMA-IR.


Fasting plasma glucose, fasting insulin and proinsulin were found to be associated with insulin resistance while none of the tested inflammatory mediators correlated significantly with insulin resistance.  Furthermore, Shehab-Eldin and colleagues found no significant difference in inflammatory mediator levels between patients and controls. In conclusion, reduced glomerular filtration rate alone were found to be associated with increased insulin resistance in previous kidney donors.


Read the abstract of the Pilot Observational Study by Shehab-Eldin et al.: Susceptibility to Insulin Resistance after Kidney Donation


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