Oxidized LDL, a novel marker in Alzheimer´s disease research
Increased plasma levels of oxidized LDL and TNF-alpha were observed in Alzheimer´s disease patients compared to age matched control subjects.
In addition, individual plasma levels of oxidized LDL were shown to be positively correlated to the percentage of TNF-alpha, PARP-1, presenilin-1 or CR38 positive cells. These findings may indicate an activation process of peripheral blood mononuclear cells by oxLDL, consistent with previous studies showing an inducation of apoptosis and inflammation by oxLDL in monocytes / macrophages as well as neurons and the production of cytokines like TNF-alpha.
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