2.4.2 Oxidized LDL improved identification of coronary artery disease patients

In 2006, Johnston and coworkers at the University Hospital, Uppsala, Sweden demonstrated that the oxLDL-to-HDL ratio was the best method to discriminate between apparently healthy men and women without clinical evidence of coronary artery disease and coronary artery disease patients, who participated in the Second Fragmin and Fast Revascularization During Instability in Coronary Artery Disease (FRISC-II) trial. This study showed that the oxLDL-to-HDL ratio could identify more patients with coronary artery disease than any other currently available blood lipid biomarker test, including, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, total cholesterol/ HDL-cholesterol ratio test, and Lp-PLA2.

Figure. Receiver-operating characteristic curves for (A) traditional lipids and lipoproteins and (B) emerging lipid and lipoprotein biomarkers HDL-C=HDL cholesterol; LDL-C=LDL cholesterol; OxLDL=oxidized LDL; TC=total cholesterol; TRIG=triglyceride. Published data by Johnston et al. (2006).

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